Acid-PEG6-mono-methyl ester
This product is a heterobifunctional PEG linker with a free carboxylic acid, a six-unit PEG spacer, and a terminal methyl ester. The free acid couples efficiently with amines to form stable amide bonds, while the methyl ester provides a protected handle for later deprotection or derivatization. The PEG6 chain offers excellent solubility and flexibility, making this reagent especially useful for stepwise conjugation and advanced bioconjugation strategies.
Key Features and Benefits
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Carboxylic Acid Group: Couples readily with primary amines for amide formation.
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Methyl Ester: Protects one end for controlled sequential modifications.
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PEG6 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
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Stepwise Conjugation: Supports orthogonal and controlled chemistry.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links biomolecules via acid/amine coupling while keeping one site protected.
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Peptide Synthesis: Introduces PEG units into peptides with controlled protection.
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Drug Delivery: Functions as a PEGylated linker in therapeutic systems.
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Organic Synthesis: Serves as a precursor for multifunctional PEG linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect the methyl ester under standard conditions when needed; prepare fresh solutions.
This product combines a reactive carboxyl with a protected ester on a PEG6 backbone, specifically offering flexibility for sequential conjugation and controlled linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
