Acid-PEG4-S-PEG4-acid
This product is a symmetric PEG-based linker containing two terminal carboxylic acid groups connected through a thioether-bridged PEG4 spacer. The dual acids allow amide coupling with amines, while the sulfur linkage and PEG chains impart hydrophilicity, flexibility, and stability, making it especially useful in bioconjugation and material science applications.
Key Features and Benefits:
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Dual Carboxylic Acids: Support efficient coupling with amines for stable amide bonds.
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Thioether Linkage: Provides stability and structural diversity for conjugates.
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PEG4 Spacers: Enhance solubility, reduce steric hindrance, and improve flexibility.
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Symmetric Design: Enables balanced dual functionalization strategies.
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High Purity: Ensures reproducibility in sensitive synthetic workflows.
Applications:
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Bioconjugation: Facilitates dual attachment of biomolecules via carboxyl–amine coupling.
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Drug Delivery: PEGylated scaffold enhances solubility and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biomaterials.
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Synthetic Chemistry: Intermediate for advanced PEGylated scaffolds and multifunctional conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) for coupling to preserve acid reactivity.
This product combines dual reactive acids with a thioether-linked PEG spacer, making it an especially versatile reagent for bioconjugation, drug delivery, and surface engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
