5-Hexynoic Acid-NHS Ester CAS:906564-59-8 is a versatile and highly efficient cross-linking reagent used in pharmaceutical research and development. Its unique chemical structure, featuring a 5-carbon alkyne moiety and N-hydroxysuccinimide (NHS) ester functionality, allows for selective conjugation to amine-containing biomolecules such as peptides, proteins, and antibodies. This targeted reactivity enables the formation of stable amide bonds while minimizing side reactions and preserving bioactivity.
5-Hexynoic Acid-NHS Ester has gained significant interest in the development of drug-delivery systems, bioconjugate chemistry, and targeted therapeutics. It is particularly valuable in the synthesis of antibody-drug conjugates (ADCs), where its robust coupling capacity ensures the precise attachment of cytotoxic agents to tumor-specific antibodies. Additionally, 5-Hexynoic Acid-NHS Ester plays a vital role in the study of protein-protein interactions, facilitating the site-specific labeling of proteins with fluorophores or other bioorthogonal moieties for real-time visualization and analysis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.