4-arm PEG Vinylsulfone, MW 10K
4-arm PEG Vinylsulfone, MW 10K is a high-purity PEG polymer with vinylsulfone termini for thiol conjugation, offering multi-point crosslinking, high solubility, flexibility, and biocompatibility. Vinylsulfone groups react selectively with thiols under mild conditions to form stable thioether bonds, making this polymer especially ideal for hydrogel formation, bioconjugation, and surface modification.
Key Features and Benefits
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Vinylsulfone Groups: React efficiently with thiols to form stable thioether linkages.
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4-Arm PEG Structure: Enables multi-point functionalization for network or crosslinked systems.
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High Molecular Weight (10K): Balances chain length for flexibility and hydrophilicity.
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Biocompatible Design: Reduces non-specific binding and immunogenicity.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
Applications
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Hydrogel Formation: Crosslink thiol-containing polymers or biomolecules for tissue engineering and drug delivery.
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Biomolecule Conjugation: Attach multiple thiol-functional ligands or peptides.
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Surface Coatings: Modify surfaces with anti-fouling PEG layers.
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Nanoparticle Functionalization: PEGylate particles for enhanced stability and stealth.
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Biomedical Devices: Create biocompatible, thiol-reactive coatings for sensors and implants.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Dissolve in an appropriate solvent before use; avoid prolonged moisture exposure to preserve vinylsulfone reactivity.
This product combines a multi-arm PEG scaffold with thiol-reactive vinylsulfone termini specifically for versatile crosslinking, hydrogel formation, and biomolecule conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.