4-Arm PLGA-SH, MW 40K is a biodegradable branched PLGA polymer with four terminal thiol groups and an approximate molecular weight of 40 kDa. Its multivalent architecture specifically supports thiol-based conjugation, crosslinking, drug delivery, and biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Creates a branched structure with four functional PLGA arms.
- Thiol Functionalization: Provides terminal sulfhydryl groups for selective conjugation and crosslinking.
- MW 40K: Supports durable polymer networks and sustained-release formulations.
- Biodegradable: PLGA hydrolyzes into lactic acid and glycolic acid under physiological conditions.
- Multivalent Reactivity: Four thiol groups support efficient crosslinking and multifunctional polymer modification.
Applications
- Bioconjugation: Couples with maleimide-functionalized biomolecules, ligands, and other thiol-reactive compounds.
- Drug Delivery: Supports biodegradable controlled and sustained-release carrier systems.
- Crosslinking: Forms polymer networks through reactions with complementary thiol-reactive groups.
- Hydrogels: Creates biodegradable crosslinked networks for hydrogel and matrix development.
- Biomaterials: Supports scaffolds, coatings, nanoparticles, and other functional biodegradable materials.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container, protected from air and moisture.
- Handling: Minimize exposure to oxidizing conditions to limit thiol oxidation and disulfide formation.
4-Arm PLGA-SH, MW 40K combines biodegradable PLGA with four reactive thiol groups to specifically support selective bioconjugation, crosslinking, drug delivery, hydrogel formation, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.