3,4-Dibromo-Mal-PEG8-t-butyl ester
This product is a high-purity, heterobifunctional PEG linker featuring a 3,4-dibromomaleimide for thiol-specific conjugation and a t-butyl ester as an acid-labile protecting group for a carboxylic acid. The PEG8 spacer enhances hydrophilicity, flexibility, and spacing between reactive groups, enabling efficient conjugation in aqueous or organic systems. This reagent is widely used in protein modification, drug-linker development, and surface functionalization.
Key Features and Benefits:
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Thiol-Reactive 3,4-Dibromomaleimide: Enables site-specific conjugation with cysteine residues or other thiol-containing molecules.
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t-Butyl Ester Protection: Preserves carboxylic acid functionality during synthesis; removable under mild acidic conditions.
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PEG8 Spacer: Improves solubility, reduces steric hindrance, and increases biocompatibility.
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Heterobifunctional Design: Supports orthogonal conjugation for multifunctional bioconjugates.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
Applications:
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Protein and Peptide Conjugation: Attach maleimide groups to biomolecules while retaining a protected acid for later activation.
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ADC and Drug-Linker Synthesis: Build antibody-drug conjugates with controlled spacing and dual functionality.
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Surface Modification: Functionalize nanoparticles, biosensors, or polymers for biological and diagnostic use.
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Multistep Organic Synthesis: Incorporate into orthogonal protection strategies for complex molecule assembly.
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Nanomedicine Research: Design targeted delivery systems with precise linker architecture.
Storage and Handling:
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Storage: Store at -20°C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to maintain maleimide and t-butyl ester stability.
3,4-Dibromo-Mal-PEG8-t-butyl ester offers thiol reactivity, acid-labile protection, and enhanced solubility, making it an especially valuable tool for bioconjugation, drug development, and advanced materials research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
