(2-pyridyldithio)-PEG2-t-butyl ester
This product is a heterobifunctional PEG2 linker with a thiol-reactive pyridyldisulfide group and a terminal t-butyl ester. The PEG2 spacer provides hydrophilicity and short flexibility, while the t-butyl ester offers acid-labile protection for controlled deprotection and orthogonal conjugation strategies.
Key Features and Benefits:
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Pyridyldisulfide Group: Reacts selectively with thiols to form reversible disulfide linkages.
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t-Butyl Ester: Acid-labile protection enabling controlled release of the carboxyl group.
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PEG2 Spacer: Provides compact hydrophilic spacing with reduced steric hindrance.
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High Purity: Ensures reproducibility in bioconjugation workflows.
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Orthogonal Reactivity: Supports multifunctional and stepwise synthesis strategies.
Applications:
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Bioconjugation: Enables thiol-specific conjugation with controlled deprotection.
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Drug Delivery: PEGylated linker improves solubility and allows triggerable release.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
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Synthetic Chemistry: Useful in designing dual-functional PEGylated scaffolds.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain disulfide and ester stability.
This product offers controlled thiol reactivity and acid-labile protection in a compact PEG framework, making it an especially versatile tool for orthogonal conjugation and advanced biomolecule engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.