2′-OMe-G(iBu)-3′-Phosphoramidite: Overview and Applications
2′-OMe-G(iBu)-3′-Phosphoramidite, CAS 150780-67-9, is a modified nucleotide designed for oligonucleotide synthesis. It features a 2′-O-methyl (OMe) group on guanosine (G) and an isobutyl (iBu) group, enhancing stability and incorporation efficiency.
Key Features:
- 2′-O-Methyl Group: Protects the 2′ hydroxyl, improving stability against nucleases and enhancing the lifetime of RNA sequences.
- Isobutyl Group: Increases hydrophobicity and aids in the solubility of the nucleotide during synthesis.
Applications:
- Oligonucleotide Synthesis: Ideal for creating stable RNA sequences with improved resistance to degradation.
- Gene Expression Studies: Enhances the effectiveness of probes and primers in RNA analysis.
- Antisense Oligonucleotides: Provides stability for therapeutic applications targeting specific RNA sequences.
- Diagnostics: Supports the development of RNA-based diagnostic assays.
2′-OMe-G(iBu)-3′-Phosphoramidite is essential for synthesizing modified RNA oligonucleotides in research, diagnostics, and therapeutic development.
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