2-methyl-3-(trimethylsilyl)cycloprop-2-ene-1-carboxylic acid
This product is a small-molecule building block featuring a strained cyclopropene, a carboxyl group, and a trimethylsilyl substituent. It is especially used in bioorthogonal chemistry and advanced synthetic applications.
Key Features and Benefits
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Cyclopropene Group: Supports fast bioorthogonal reactions with tetrazines.
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Carboxyl Group: Enables amide coupling with primary amines.
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Trimethylsilyl Substitution: Provides synthetic stability and tunable reactivity.
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Compact Design: Minimizes steric hindrance in conjugation.
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High Purity: Ensures reproducibility in chemical biology and synthesis.
Applications
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Bioorthogonal Chemistry: Reacts with tetrazines in strain-promoted cycloaddition.
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Bioconjugation: Couples with amines via the carboxyl handle.
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Probe Development: Serves as a precursor for labeling molecules.
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Organic Synthesis: Provides a versatile building block for linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates cyclopropene click reactivity with carboxyl conjugation, specifically providing a powerful tool for synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
