methyl-TMS-cyclopropenylmethanol
This product is a compact strained-ring alcohol functionalized with a trimethylsilyl (TMS)-substituted cyclopropene. The cyclopropenyl moiety enables rapid bioorthogonal reactions, while the hydroxymethyl group provides a handle for derivatization, making this reagent valuable for click chemistry, probe design, and advanced bioconjugation.
Key Features and Benefits:
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Cyclopropenyl Group: Strained alkyne analog enabling fast IEDDA click reactions with tetrazines.
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Trimethylsilyl Substitution (TMS): Enhances stability and fine-tunes reactivity.
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Hydroxymethyl Group: Versatile functional handle for further chemical modification.
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Compact Design: Small size reduces steric hindrance in conjugation.
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High Purity: Ensures reproducibility in bioconjugation and synthetic chemistry.
Applications:
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Click Chemistry: IEDDA ligation with tetrazines for bioorthogonal labeling.
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Bioconjugation: Enables site-specific protein, peptide, and small-molecule modification.
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Probe Development: Incorporates into imaging agents or diagnostic tools.
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Synthetic Chemistry: Useful intermediate in constructing strained-ring derivatives.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed container, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF, acetonitrile) under inert atmosphere to maintain stability.
This product combines the reactivity of a strained cyclopropenyl system with a hydroxymethyl handle, making it an especially versatile building block for bioorthogonal chemistry and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
