2-Hydroxyethyl disulfide mono-Tosylate
2-Hydroxyethyl disulfide mono-Tosylate is a high-purity heterobifunctional reagent with a terminal hydroxyl group and a tosyl-activated alcohol on opposite ends of a disulfide bridge. The hydroxyl group can be further derivatized, while the tosylate serves as an excellent leaving group for nucleophilic substitution, enabling the introduction of diverse functional groups. The disulfide bond allows for cleavable linkages, making this reagent especially ideal for reversible conjugation, crosslinking, and redox-sensitive bioconjugates.
Key Features and Benefits
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Tosyl Group: Highly reactive toward nucleophiles for efficient substitution reactions.
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Hydroxyl Group: Versatile handle for further chemical modification.
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Disulfide Linkage: Enables cleavable, redox-sensitive conjugation.
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Heterobifunctional Design: Facilitates orthogonal modification strategies.
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High Purity: Supplied at >95% purity for reproducible performance.
Applications
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Synthesis of cleavable linkers and crosslinkers.
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Redox-sensitive bioconjugate development.
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Introduction of thiol groups via disulfide exchange.
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Preparation of functionalized polymers and biomaterials.
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Controlled release systems in drug delivery.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain tosyl reactivity.
This product offers a hydroxyl group for derivatization, a tosyl group for nucleophilic substitution, and a cleavable disulfide specifically for reversible conjugation in chemical and biological applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
