2′-F-Bz-dC Phosphoramidite (also known as DMT-2′-Fluoro-dC(Bz) Phosphoramidite, CAS 161442-19-9) is a fluorine-modified deoxycytidine phosphoramidite with a fluorine atom at the 2′ position and a cytidine capped with a benzoyl functional group. This modification increases the stability of DNA oligonucleotides, improving their resistance to enzymatic degradation. The benzoyl group protects the exocyclic amine of cytosine, ensuring controlled and precise oligonucleotide assembly during synthesis.
Key Features:
- CAS Number: 161442-19-9
- Other Names: DMT-2′-Fluoro-dC(Bz) Phosphoramidite
- Chemical Structure: 2′-Fluoro-modified deoxycytidine with benzoyl-capped cytidine
- Function: Fluorinated building block for DNA oligonucleotide synthesis
- Protection Groups: Benzoyl on cytosine amine, DMT for 5′ hydroxyl
- Applications:
- Enhances oligonucleotide stability for therapeutic and diagnostic purposes
- Ideal for solid-phase DNA synthesis in research and drug development
2′-F-Bz-dC Phosphoramidite provides increased stability and precise synthesis, making it an excellent choice for developing more durable oligonucleotides in genetic research, diagnostics, and therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
