2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a high-purity heterobifunctional PEG linker featuring an azide group for bioorthogonal click chemistry (CuAAC or SPAAC) and a terminal carboxylic acid for versatile coupling to amines or other nucleophiles. The PEG8 spacer provides excellent aqueous solubility, high flexibility, and reduced steric hindrance, enabling efficient bioconjugation in both aqueous and organic environments. This reagent is ideal for applications requiring long, hydrophilic linkers for improved accessibility and reduced aggregation.
Key Features and Benefits
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Azide Functional Group: Compatible with copper-catalyzed and strain-promoted azide–alkyne cycloaddition for bioorthogonal labeling.
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Carboxylic Acid Group: Allows further coupling via carbodiimide chemistry (e.g., EDC/NHS) to primary amines.
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PEG8 Spacer: Enhances solubility, flexibility, and functional group accessibility.
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Heterobifunctional Design: Supports orthogonal, sequential conjugation strategies.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
Applications
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Click Chemistry Bioconjugation: Link biomolecules via azide–alkyne cycloaddition.
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Protein and Peptide Modification: Add hydrophilic spacers for improved stability and reduced aggregation.
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Nanoparticle Functionalization: Introduce bioorthogonal handles for targeted delivery systems.
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Drug Delivery Systems: Construct linkers enabling precise payload attachment and controlled release.
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Diagnostic Probe Development: Build multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents; avoid prolonged exposure to moisture to preserve reactivity.
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid combines azide click chemistry reactivity with a carboxylic acid coupling site, offering especially excellent solubility and flexibility for constructing multifunctional bioconjugates, precision linkers, and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
