DibromoMal-PEG1-Folate
This product is a multifunctional linker combining a dibromomaleimide (DibromoMal) group, a short PEG1 spacer, and a folate moiety. The DibromoMal group enables selective conjugation with thiols, forming stable thioether linkages, while also supporting reversible crosslinking under specific conditions. The PEG1 spacer specifically enhances solubility with minimal added length, and the folate unit targets folate receptor–expressing cells, making this reagent especially useful for targeted drug delivery and probe design.
Key Features and Benefits
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DibromoMaleimide Group: Reacts selectively with thiols, enabling stable or reversible conjugation.
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PEG1 Spacer: Provides compact solubility and reduces steric hindrance.
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Folate Moiety: Ensures high-affinity targeting of folate receptor–positive cells.
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Targeted Delivery: Combines receptor targeting with thiol-based conjugation.
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High Purity: Produced to ≥95% purity for consistent performance.
Applications
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Targeted Drug Delivery: Directs conjugates to folate receptor–expressing tumors.
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Antibody–Drug Conjugates (ADCs): Serves as a receptor-targeting linker for controlled payload delivery.
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Probe Development: Builds folate-targeted probes for imaging and diagnostics.
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Bioconjugation: Couples thiol-containing biomolecules with folate for selective targeting.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Dissolve freshly in dry solvent before use; avoid repeated freeze–thaw cycles.
This product integrates thiol-reactive conjugation with folate receptor targeting in a compact PEG1 design, specifically providing a powerful tool for selective drug delivery and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
