Amino-PEG8-CH2CO2-t-butyl ester
This product is a high-purity heterobifunctional PEG linker with a primary amine and a tert-butyl-protected carboxylic acid. The PEG8 spacer specifically improves solubility, flexibility, and reduces steric hindrance. The amine reacts with carboxylic acids or NHS esters, while the tert-butyl ester can be deprotected under mild acidic conditions to yield a free acid for further functionalization, enabling especially versatile bioconjugation and material modification.
Key Features and Benefits
-
Primary Amine: Forms stable amide bonds with activated esters or carboxylic acids.
-
t-Butyl Ester Protection: Allows controlled deprotection for subsequent conjugation steps.
-
PEG8 Spacer: Enhances solubility and accessibility of reactive groups.
-
Heterobifunctional Design: Enables orthogonal conjugations in multi-step syntheses.
-
High Purity: Supplied at >95% purity for reproducibility.
Applications
-
Protein, peptide, and small molecule conjugation.
-
Surface and nanoparticle functionalization.
-
PEGylation in drug delivery and diagnostics.
-
Multi-step orthogonal labeling strategies.
-
Advanced biomaterials development.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
This product combines an amine for coupling with a protected acid for orthogonal conjugation, linked by a PEG8 spacer specifically for optimal solubility and flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
