Amino-PEG1-CH2CO2-t-butyl ester
Amino-PEG1-CH2CO2-t-butyl ester is a high-purity heterobifunctional PEG linker with a primary amine for versatile conjugation and a t-butyl ester-protected carboxylic acid for controlled activation. The short PEG1 spacer enhances solubility while maintaining a compact structure, reducing steric hindrance and enabling efficient bioconjugation in both aqueous and organic systems. The t-butyl ester protects the carboxylic acid until mild acidic deprotection, allowing stepwise conjugation strategies.
Key Features and Benefits
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Primary Amine: Reacts readily with NHS esters, isocyanates, aldehydes, and other electrophiles.
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t-Butyl Ester-Protected Carboxylic Acid: Stable under neutral and basic conditions; easily deprotected to a reactive acid.
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PEG1 Spacer: Improves solubility and accessibility of reactive groups with minimal chain length.
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Heterobifunctional Design: Enables orthogonal and sequential modification strategies.
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High Purity: Supplied at >95% purity for reliable and reproducible results.
Applications
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Stepwise Bioconjugation: Protect the carboxylic acid for controlled timing of functionalization.
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Protein and Peptide Modification: Attach amines to biomolecules while reserving acid reactivity for later steps.
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Nanoparticle and Surface Functionalization: Introduce amine groups and a latent acid for dual reactivity.
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Drug Delivery Systems: Incorporate protected acid handles for post-conjugation payload attachment.
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Diagnostic and Imaging Probes: Create multifunctional probes with sequential modification capability.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to preserve reactivity.
This product combines a primary amine with a protected carboxylic acid in a compact PEG1 framework, specifically offering flexibility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
