HO-PEG4-Benzyl Ester
HO-PEG4-benzyl ester is a high-purity PEG linker with a terminal hydroxyl group for versatile derivatization and a benzyl ester–protected carboxyl group for selective deprotection under mild hydrogenolysis conditions. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient conjugation in both aqueous and organic systems.
Key Features and Benefits
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Hydroxyl Group – Serves as a versatile handle for further functionalization.
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Benzyl Ester Protection – Cleavable by mild hydrogenolysis, allowing orthogonal conjugation strategies.
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PEG4 Spacer – Improves aqueous solubility, molecular flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Supports sequential functionalization without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible results.
Applications
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Stepwise functionalization and linker synthesis
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Polymer and surface modification
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Prodrug and drug delivery system development
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Multifunctional bioconjugate synthesis
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product combines a hydroxyl group for derivatization with a benzyl-protected carboxyl, separated by a PEG4 spacer for solubility and flexibility, making it especially ideal for orthogonal conjugation strategies in research and drug development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.