HO-PEG8-t-butyl ester
This poduct is a monofunctional PEG linker featuring a hydroxyl group and a t-butyl ester-protected carboxyl group. The PEG8 spacer enhances solubility and flexibility, while the t-butyl ester specifically enables selective deprotection under mild acidic conditions for subsequent conjugation.
Key Features
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Hydroxyl group for further derivatization
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t-Butyl ester-protected carboxyl for acid-labile deprotection
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PEG8 spacer for improved solubility and reduced steric hindrance
Applications
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Synthesis of PEGylated compounds
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Prodrug and polymer–drug conjugate development
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Surface and material modification requiring acid-cleavable linkers
Storage and Handling
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Store at –20 °C, protected from moisture
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Warm to room temperature before opening to avoid condensation
This product is a versatile PEG building block offering a hydroxyl handle for derivatization and an acid-labile t-butyl ester specifically for controlled release or further conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
