Cbz-N-Amido-PEG10-CH2COOH
Cbz-N-Amido-PEG10-CH2COOH is a high-purity heterobifunctional PEG derivative featuring a terminal carbobenzyloxy (Cbz)-protected amine and a carboxylic acid (-COOH) group. The Cbz group provides temporary amine protection, allowing orthogonal functionalization, while the PEG10 spacer specifically improves hydrophilicity, solubility, and flexibility, reducing steric hindrance during conjugation in both aqueous and organic systems.
Key Features
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Cbz-protected amine for orthogonal synthetic strategies
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Terminal carboxylic acid for coupling via EDC/NHS or other carbodiimide chemistry
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PEG10 spacer enhances water solubility and reduces aggregation
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High chemical stability and purity
Applications
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Sequential conjugation of biomolecules with orthogonal protection strategies
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PEGylation of proteins, peptides, and small molecules
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Synthesis of multifunctional linkers for drug delivery and diagnostics
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Nanoparticle and polymer surface modification
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product contains a Cbz-protected amine for orthogonal conjugation and a carboxylic acid group for efficient coupling, connected by a PEG10 spacer specifically for enhanced solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
