PLLA-PEG-Amine (PLLA-PEG-NH2), MW x 3K, n 1K is an amine-functionalized biodegradable block copolymer and specifically combines a 3K PLLA segment, 1K PEG segment, and terminal primary amine (–NH₂) for conjugation and biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: PLLA-PEG-Amine combines hydrophobic poly(L-lactide) with hydrophilic polyethylene glycol.
- PLLA MW 3K: The 3K PLLA segment provides a biodegradable and hydrophobic polyester component.
- PEG MW 1K: The 1K PEG segment provides a compact hydrophilic spacer specifically for functional polymer systems.
- Primary Amine Functionality: The terminal –NH₂ group specifically provides a reactive site for further chemical modification.
- Amine-Reactive Coupling: The primary amine reacts with NHS esters, activated carboxyl groups, and other compatible amine-reactive groups.
- Stable Amide Formation: The amine supports covalent conjugation specifically through stable amide bonds under suitable coupling conditions.
- Amphiphilic Character: Hydrophobic PLLA and hydrophilic PEG support self-assembly in compatible formulation systems.
- Biodegradable Polymer Platform: PLLA provides a biodegradable polyester component for polymer and biomaterial research.
Applications
- Bioconjugation: PLLA-PEG-Amine (PLLA-PEG-NH2) provides terminal amine functionality for attaching compatible biomolecules and probes.
- Ligand Conjugation: Supports attachment of suitable ligands through amine-reactive coupling chemistry.
- Nanoparticle Research: The amphiphilic block structure supports development of polymeric nanoparticles and related nanoscale assemblies.
- Polymeric Micelles: Hydrophobic PLLA and hydrophilic PEG support self-assembly into compatible polymeric systems.
- Drug Delivery Research: Supports development of experimental polymer-based delivery and controlled-release systems.
- Surface Modification: The terminal amine provides functionality for polymer and material surface modification.
- Polymer Functionalization: Provides a reactive starting material for preparing additional PLLA-PEG derivatives.
- Biomaterial Research: Supports development of biodegradable polymer systems, conjugates, nanoparticles, and functional materials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Amine (PLLA-PEG-NH2), MW x 3K, n 1K combines biodegradable PLLA, compact PEG, and reactive primary amine functionality and specifically supports conjugation, self-assembly, nanoparticle formulation, polymer modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.