PLLA-PEG-Alkyne, MW x 10K, n 2K combines a 10K PLLA segment, 2K PEG segment, and terminal alkyne functionality in a biodegradable block copolymer and specifically supports click chemistry, bioconjugation, nanoparticle development, and functional biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic poly(L-lactide) (PLLA) with hydrophilic polyethylene glycol (PEG) for amphiphilic polymer design.
- PLLA MW 10K: The 10K PLLA segment provides a biodegradable hydrophobic component suitable for polymer assembly and material research.
- PEG MW 2K: The 2K PEG segment specifically provides a hydrophilic component and flexible polymer spacer for conjugation and formulation studies.
- Alkyne Functionality: Terminal alkyne provides a reactive site specifically for selective conjugation with compatible azide-functionalized molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with azides to form stable triazole linkages.
- Stable Triazole Formation: Click reactions provide stable covalent linkages specifically for polymer functionalization and conjugate development.
- Amphiphilic Character: PLLA and PEG provide distinct hydrophobic and hydrophilic regions for self-assembly and formulation research.
- Biodegradable Polymer Platform: Combines biodegradable PLLA with hydrophilic PEG and click-reactive functionality for versatile material development.
Applications
- Click Chemistry: Supports CuAAC conjugation with compatible azide-functionalized molecules and materials.
- Bioconjugation: Attachment of peptides, ligands, dyes, and other azide-functionalized molecules through click chemistry.
- Ligand Conjugation: Preparation of functional polymer conjugates for targeting and molecular recognition research.
- Nanoparticle Research: Development and functionalization of polymeric nanoparticles and related nanoscale systems.
- Polymeric Micelles: Amphiphilic PLLA and PEG blocks support research into self-assembled polymeric structures.
- Drug Delivery Research: Development and evaluation of biodegradable polymer-based delivery systems.
- Surface Modification: Alkyne functionality enables click-mediated modification of compatible azide-functionalized surfaces and materials.
- Biomaterial Research: Development of biodegradable, PEG-containing functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Alkyne, MW x 10K, n 2K combines biodegradable PLLA, hydrophilic PEG, and click-reactive alkyne functionality, while its block composition supports conjugation, self-assembly, nanoparticle, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.