t-Boc-N-Amido-PEG1-CH2COOH
This product is a compact PEG1 linker with a Boc-protected amide and a terminal carboxymethyl group. The short PEG1 spacer provides limited hydrophilicity and spacing, while the Boc group offers acid-labile protection for orthogonal and controlled conjugation strategies.
Key Features and Benefits:
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Boc-Protected Amide: Acid-labile protection for stepwise, selective synthesis.
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Carboxymethyl Group: Couples efficiently with amines to form stable amide bonds.
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PEG1 Spacer: Compact hydrophilic chain with minimal steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Reactivity: Combines protection and carboxyl coupling for multifunctional use.
Applications:
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Bioconjugation: Enables precise biomolecule attachment with minimal PEG spacing.
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Drug Delivery: Improves solubility and stability in conjugated therapeutics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, or hydrogels.
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Synthetic Chemistry: Useful intermediate in orthogonal conjugation and scaffold design.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and carboxyl stability.
This product combines short PEG spacing with dual reactivity, making it an especially efficient reagent for orthogonal synthesis, conjugation, and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
