PDLLA-PEG-NH2, MW x 10K, n 1K is an amine-functionalized amphiphilic block copolymer. It combines 10K hydrophobic PDLLA with 1K hydrophilic PEG and a terminal amine specifically for conjugation, polymer functionalization, and drug-delivery research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 10K: Provides a biodegradable hydrophobic block for polymer assembly and incorporation of hydrophobic compounds.
- PEG MW 1K: Provides a short hydrophilic segment for surface presentation and aqueous interfacial properties.
- Terminal Amine Group: Provides a primary amine for conjugation with compatible amine-reactive molecules and functional groups.
- Amine-Reactive Coupling: Supports reactions with activated carboxyl groups, NHS esters, and other compatible amine-reactive functionalities.
- Bioconjugation Platform: Enables attachment of compatible peptides, proteins, ligands, dyes, and other functional molecules.
- PDLLA-Rich Architecture: The 10:1 PDLLA-to-PEG molecular weight ratio especially favors hydrophobic character with a short functional PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages support gradual degradation of the PDLLA segment under appropriate conditions.
Applications
- Bioconjugation: Terminal amine supports coupling with compatible amine-reactive biomolecules and functional compounds.
- Polymer Functionalization: Provides a primary amine specifically for introducing additional functional groups onto the polymer terminus.
- Polymer Self-Assembly: Supports formation of PDLLA-rich amphiphilic polymer assemblies.
- Nanoparticle Functionalization: Enables amine-mediated surface modification of compatible PEG-containing polymeric nanoparticles.
- Ligand Conjugation: Supports attachment of compatible targeting ligands and other functional molecules.
- Drug Delivery: Supports development of functional amphiphilic polymers for drug-delivery and formulation research.
- Surface Modification: Terminal amine provides a reactive handle for modifying compatible polymer assemblies and surfaces.
- Biomaterial Research: Supports development of functional polymer conjugates, nanoparticles, assemblies, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-NH2, MW x 10K, n 1K combines biodegradable PDLLA, a short PEG segment, and terminal amine functionality, while its 10:1 PDLLA-rich architecture supports bioconjugation, polymer assembly, nanoparticle functionalization, and drug-delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.