PDLLA-PEG-N3, MW x 16K, n 2K is an azide-functionalized amphiphilic block copolymer. It combines 16K hydrophobic PDLLA with 2K hydrophilic PEG and a terminal azide specifically for click chemistry and bioconjugation research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 16K: Provides a biodegradable hydrophobic block for polymer assembly and incorporation of hydrophobic compounds.
- PEG MW 2K: Provides a compact hydrophilic segment for aqueous compatibility, steric stabilization, and surface presentation.
- Terminal Azide Group: Provides an azide functionality for selective click chemistry with compatible alkyne-containing molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkynes.
- SPAAC Click Chemistry: Supports copper-free coupling with strained cyclooctynes such as DBCO and BCN.
- Bioconjugation Platform: Enables attachment of compatible peptides, proteins, ligands, dyes, and other functional molecules.
- PDLLA-Rich Architecture: The 8:1 PDLLA-to-PEG molecular weight ratio especially favors hydrophobic character while retaining a functional PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages specifically support gradual degradation of the PDLLA segment under appropriate conditions.
Applications
- Click Chemistry: Terminal azide supports CuAAC and SPAAC reactions with compatible alkyne-functionalized molecules.
- Bioconjugation: Enables attachment of compatible biomolecules, ligands, dyes, and other functional compounds through click chemistry.
- Polymer Functionalization: Provides an azide handle for introducing additional functionality onto the PEG terminus.
- Polymer Self-Assembly: Supports formation of PDLLA-rich amphiphilic polymer assemblies.
- Nanoparticle Functionalization: Enables click-mediated modification of compatible PEG-containing polymeric nanoparticles.
- Ligand Conjugation: Supports attachment of compatible alkyne- or cyclooctyne-functionalized ligands.
- Drug Delivery: Supports development of functional amphiphilic polymers for drug-delivery and formulation research.
- Biomaterial Research: Supports development of functional polymer conjugates, nanoparticles, assemblies, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-N3, MW x 16K, n 2K combines biodegradable PDLLA, hydrophilic PEG, and terminal azide functionality, while its 8:1 architecture supports click chemistry, bioconjugation, polymer assembly, and nanoparticle functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.