PDLLA-PEG-COOH, MW x 10K, n 2K is a carboxyl-functionalized amphiphilic block copolymer. It combines 10K hydrophobic PDLLA with 2K hydrophilic PEG specifically for conjugation, polymer functionalization, and drug-delivery research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PDLLA with hydrophilic PEG for polymer assembly, formulation, and biomaterial development.
- PDLLA MW 10K: Provides a biodegradable hydrophobic block for core formation, polymer assembly, and incorporation of hydrophobic compounds.
- PEG MW 2K: Provides a compact hydrophilic segment specifically for aqueous compatibility, steric stabilization, and surface presentation.
- Terminal Carboxyl Group: Provides a reactive COOH group for conjugation and further chemical modification.
- Amide Coupling Platform: The terminal COOH group supports coupling with primary amines after suitable activation, including EDC/NHS chemistry.
- PDLLA-Rich Architecture: The 5:1 PDLLA-to-PEG molecular weight ratio especially favors hydrophobic character while retaining a functional PEG segment.
- Biodegradable PDLLA Block: Hydrolyzable ester linkages specifically support gradual degradation of the PDLLA segment under appropriate conditions.
- Functional Polymer Platform: Terminal COOH supports modification with compatible amine-containing ligands, biomolecules, and functional components.
Applications
- Polymer Functionalization: Supports attachment of compatible amine-containing molecules through activated carboxyl chemistry.
- EDC/NHS Coupling: The terminal COOH group can undergo activation for subsequent reaction with primary amines.
- Bioconjugation: Supports conjugation with compatible peptides, proteins, ligands, and other amine-containing molecules.
- Polymer Self-Assembly: Supports formation of PDLLA-rich amphiphilic polymer assemblies.
- Nanoparticle Functionalization: Enables surface modification of compatible PEG-containing polymeric nanoparticles.
- Drug Delivery: Supports development of functional amphiphilic polymers for drug-delivery and controlled-release research.
- Surface Modification: Terminal COOH provides a functional handle for modifying compatible polymer assemblies and surfaces.
- Biomaterial Research: Supports development of functional polymer conjugates, nanoparticles, assemblies, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PDLLA-PEG-COOH, MW x 10K, n 2K combines biodegradable PDLLA, hydrophilic PEG, and terminal carboxyl functionality, while its PDLLA-rich architecture supports conjugation, polymer assembly, nanoparticle functionalization, and drug-delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.