t-Boc-N-Amido-PEG4-amine
This product is a bifunctional PEG4 linker with a Boc-protected amide and a terminal primary amine. The PEG4 spacer improves solubility and flexibility, while the Boc group provides acid-labile protection for controlled, orthogonal conjugation.
Key Features and Benefits:
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Boc-Protected Amide: Stable, acid-labile protection for stepwise synthesis.
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Terminal Amine Group: Reacts efficiently with carboxyls, NHS esters, or other electrophiles.
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PEG4 Spacer: Enhances hydrophilicity, flexibility, and reduces steric hindrance.
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High Purity: Ensures reliable performance in sensitive bioconjugation workflows.
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Orthogonal Reactivity: Supports selective, multistep conjugation strategies.
Applications:
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Bioconjugation: Attach proteins, peptides, or small molecules with precise control.
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Drug Delivery: PEGylated linker to improve solubility and pharmacokinetics.
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Surface Functionalization: Modify nanoparticles, hydrogels, or polymers.
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Synthetic Chemistry: Useful in PEGylated intermediates for advanced materials.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve reactivity.
This product provides a short PEG spacer with Boc-protected and amine functionalities, making it an especially versatile reagent for controlled conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
