t-Boc-N-Amido-PEG3-amine
This product is a bifunctional PEG3 linker with a Boc-protected amide and a terminal primary amine. The short PEG3 spacer provides solubility and flexibility, while the Boc group offers acid-labile protection for controlled, orthogonal conjugation strategies.
Key Features and Benefits:
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Boc-Protected Amide: Acid-labile protection for selective deprotection in stepwise synthesis.
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Amine Group: Couples efficiently with carboxyls, NHS esters, and other electrophiles.
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PEG3 Spacer: Provides compact hydrophilicity and reduced steric hindrance.
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High Purity: Ensures reliable performance in sensitive conjugation workflows.
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Orthogonal Reactivity: Supports controlled, multistep synthetic strategies.
Applications:
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Bioconjugation: Enables attachment of proteins, peptides, or biomolecules with short PEG spacing.
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Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, and polymers.
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Synthetic Chemistry: Useful intermediate in PEG-based scaffold construction.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and amine reactivity.
This product combines a short PEG spacer with a Boc-protected amide and a reactive amine, making it an especially versatile reagent for orthogonal conjugation and controlled synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
