Fmoc-PEG8-NHS ester
This product is a heterobifunctional PEG linker featuring an Fmoc-protected amine and an NHS ester for efficient amine conjugation. The PEG8 spacer enhances solubility, flexibility, and steric spacing, making it especially useful for orthogonal synthesis, bioconjugation, and drug delivery applications.
Key Features and Benefits:
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Fmoc-Protected Amine: Base-labile protection supports orthogonal, stepwise synthesis.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG8 Spacer: Improves solubility, hydrophilicity, and accessibility.
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Orthogonal Reactivity: Enables multifunctional conjugation strategies.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Couples biomolecules with orthogonal PEG-based chemistry.
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Drug Delivery: Builds PEGylated linkers for enhanced solubility and circulation.
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Probe Development: Constructs multifunctional imaging and diagnostic probes.
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Peptide Chemistry: Serves as an intermediate for protected syntheses.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve ester reactivity.
This product combines Fmoc protection with amine-reactive NHS chemistry in a PEG8 scaffold, making it an especially versatile linker for synthesis, drug delivery, and multifunctional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
