α‑Hydroxyl‑ω‑Amine‑poly(L‑lactide) (PLLA‑NH₂, MW 20K) is linear, mono‑amine‑terminated semi‑crystalline biodegradable aliphatic polyester. The polymer backbone consists of stereoregular L‑lactide repeating units with high crystallinity, distinctly different from fully‑amorphous PDLLA. Within the PLLA‑NH₂ product series, this 20 kDa grade delivers the highest hydrophobicity and exhibits ultra‑slow homogeneous hydrolytic degradation rate. One polymer terminus bears nucleophilic primary amine (‑NH₂) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal primary amine can form stable amide bonds with carboxyl‑containing molecules under EDC/NHS activation, and readily reacts with NHS‑ester, aldehyde, isocyanate and epoxy moieties for covalent bioconjugation with peptides, proteins and targeting ligands. It acts as monofunctional macromolecular initiator and modification building block for implant‑relevant scaffolds, high‑strength microspheres and ultra‑long‑term sustained‑release biomedical research.
Key Features
- MW: 20000 Da, linear α‑hydroxyl‑ω‑amine‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Highest hydrophobicity in PLLA‑NH₂ series, ultra‑slow and uniform hydrolytic degradation
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal primary amine (‑NH₂) group with high nucleophilic reactivity for amide coupling and multiple organic reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high amine end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Amine group is moisture‑sensitive; avoid prolonged exposure to humid air and acidic contaminants
Applications
- Monofunctional building block for amide‑based bioconjugation with carboxyl‑modified peptides, proteins and targeting moieties
- Macro‑initiator for NCA ring‑opening polymerization to synthesize high‑molecular‑weight PLLA‑based block copolymers
- Fabrication of amine‑functional high‑crystallinity PLLA microspheres and porous tissue‑engineering scaffolds for ultra‑long‑term sustained‑release drug‑delivery research
- Amino surface modification of high‑strength polyester implant materials to enhance cell adhesion and biological affinity
- Research‑grade raw material for constructing high‑molecular‑weight degradable biomedical polymer conjugates
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; humidity may deactivate amine end‑groups and accelerate polyester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.