PDLLA-Amine (PDLLA-NH2), MW 16K is an amine-functionalized poly(DL-lactide) with a molecular weight of approximately 16K. It combines a biodegradable amorphous PDLLA backbone with terminal primary amine functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amine-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal primary amine group for chemical modification and conjugation.
- MW 16K: Provides an intermediate molecular weight that specifically balances polymer processability, biodegradable matrix formation, and functionalization.
- Primary Amine Functionality: The terminal –NH2 group provides a reactive site specifically for coupling with carboxyl, NHS ester, isocyanate, and other amine-reactive functional groups.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Versatile Conjugation Platform: Primary amine functionality enables attachment of compatible polymers, biomolecules, ligands, probes, and other functional components.
- Surface Functionalization: The terminal amine provides a convenient reactive handle for modifying particles, coatings, surfaces, and polymeric materials.
Applications
- Bioconjugation: Supports coupling of PDLLA with compatible biomolecules, peptides, proteins, ligands, and other functional components.
- Amide Coupling: Enables conjugation with carboxyl-containing molecules through appropriate coupling chemistry.
- NHS Ester Conjugation: Supports efficient reaction with NHS ester-functionalized molecules and materials.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of amine functionality into PDLLA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems specifically for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Amine (PDLLA-NH2), MW 16K provides an amorphous biodegradable PDLLA platform with terminal primary amine functionality for versatile conjugation and functionalization and specifically supports bioconjugation, polymer modification, nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.