PDLLA-Amine (PDLLA-NH2), MW 10K is an amine-functionalized poly(DL-lactide) with a molecular weight of approximately 10K. It combines a biodegradable amorphous PDLLA backbone with terminal primary amine functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amine-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal primary amine group for chemical modification and conjugation.
- MW 10K: Provides a lower molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Primary Amine Functionality: The terminal –NH2 group provides a reactive site specifically for coupling with carboxyl, NHS ester, isocyanate, and other amine-reactive functional groups.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Versatile Conjugation Platform: Primary amine functionality enables attachment of compatible polymers, biomolecules, ligands, probes, and other functional components.
Applications
- Bioconjugation: Supports coupling of PDLLA with compatible biomolecules, peptides, proteins, ligands, and other functional components.
- Amide Coupling: Enables conjugation with carboxyl-containing molecules through appropriate coupling chemistry.
- NHS Ester Conjugation: Supports efficient reaction with NHS ester-functionalized molecules and materials.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of amine functionality into PDLLA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Amine (PDLLA-NH2), MW 10K provides an amorphous biodegradable PDLLA platform with terminal primary amine functionality and good processability and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.