PDLLA-Amine (PDLLA-NH2), MW 5K is an amine-functionalized poly(DL-lactide) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable amorphous PDLLA backbone with terminal primary amine functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amine-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal primary amine group for chemical modification and conjugation.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Primary Amine Functionality: The terminal –NH2 group provides a reactive site specifically for coupling with carboxyl, NHS ester, isocyanate, and other amine-reactive functional groups.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Versatile Conjugation Platform: Primary amine functionality enables attachment of compatible polymers, biomolecules, ligands, probes, and other functional components.
Applications
- Bioconjugation: Supports coupling of PDLLA with compatible biomolecules, peptides, proteins, ligands, and other functional components.
- Amide Coupling: Enables conjugation with carboxyl-containing molecules through appropriate coupling chemistry.
- NHS Ester Conjugation: Supports efficient reaction with NHS ester-functionalized molecules and materials.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of amine functionality into PDLLA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Amine (PDLLA-NH2), MW 5K provides a low-molecular-weight, amorphous biodegradable PDLLA platform with terminal primary amine functionality and good processability and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.