PLGA-Fluorescein (PLGA-FITC), MW 20K is an ultra-high-molecular-weight fluorescein-terminated fluorescent biodegradable PLGA copolymer engineered for ultra-long-cycle biological tracing, high-stability nanoparticle imaging, and multi-stage sustained drug delivery visualization. Featuring standard FITC fluorescent labeling and fully customizable PLGA lactide ratios, this polymer delivers ultra-stable low-background green fluorescence and exceptional structural rigidity, perfectly suited for long-term in vivo imaging, durable carrier tracking and long-acting biomedical formulation research.
Basic Specifications
Alternative Name: PLGA-Fluorescein, PLGA-FITC
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Fluorescent Label: Fluorescein (FITC)
Excitation Wavelength: ~495 nm
Emission Wavelength: ~519 nm
Molecular Weight: 20K, Custom
Appearance: Yellow to yellow-green solid
Key Features and Benefits
Stable FITC Fluorescent Labeling: Terminal fluorescein (FITC) functionalization provides bright, consistent green fluorescence with standard ~495 nm excitation and ~519 nm emission peaks. It exhibits minimal biological background interference and high-sensitivity optical signals, maintaining stable fluorescence output throughout ultra-long experimental and in vivo degradation cycles.
Multi-Ratio & Custom Synthesis Support: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Accurate ratio modulation precisely adjusts polymer hydrophobicity, mechanical toughness and ultra-long degradation kinetics to meet diverse long-acting sustained-release and high-stability imaging scenarios.
Ultra-Stable 20K Ultra-High Molecular Weight Performance: 20K ultra-high molecular weight forms dense polymer chain entanglement, delivering exceptional structural rigidity, anti-deformation performance and morphological stability superior to low and medium MW PLGA. It features significantly prolonged, uniform degradation behavior, effectively preventing particle rupture, structural fatigue and premature drug leakage for ultra-long-cycle fluorescent delivery systems.
Superior Biocompatibility & Mild Biodegradability: Possesses excellent physiological compatibility and biosafety, undergoing mild, uniform hydrolysis into non-toxic lactic acid and glycolic acid under physiological conditions. No inflammatory irritation or toxic residue occurs, fully compliant with long-term in vivo implantation and prolonged biomedical tracing requirements.
Long-Duration Fluorescence Stability: Precision terminal FITC capping technology effectively avoids fluorophore shedding, migration and fluorescence quenching during long-term particle storage, in vivo circulation and slow polymer degradation, ensuring durable, repeatable high-sensitivity fluorescent imaging results.
Applications
Ultra-Long-Term Fluorescent Particle Tracing: Specially optimized for multi-month prolonged real-time tracking and tissue distribution analysis of PLGA nanoparticles and microspheres, supporting ultra-long-cycle biological behavior monitoring and mechanism research.
Long-Cycle Sustained Drug Delivery Imaging: Enables continuous visual monitoring of ultra-slow carrier degradation, long-term in vivo accumulation, tissue retention and sustained drug release kinetics for long-acting controlled-release formulation development.
Durable Biomedical Fluorescent Labeling: Serves as a high-rigidity self-fluorescent polymer matrix for long-term implantable biomaterial labeling, persistent biological distribution evaluation and long-cycle optical detection experiments.
High-Stability Long-Cycle Formulation Research: Facilitates intuitive assessment of long-term nanoparticle structural stability, sustained cellular uptake performance and ultra-long delivery efficiency for advanced long-acting drug delivery system research.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container to fully preserve long-term FITC fluorescence activity and polymer structural integrity.
Handling: Avoid strong light irradiation, repeated freeze-thaw cycles and high-temperature environments to prevent fluorescence quenching and premature polymer hydrolysis.
PLGA-Fluorescein (PLGA-FITC), MW 20K integrates ultra-high structural stability, long-cycle tunable degradability and durable FITC green fluorescence, serving as a high-end fluorescent tracing polymer for ultra-long-term drug delivery imaging, durable nanoparticle tracking and high-standard advanced biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.