PLGA-Fluorescein (PLGA-FITC), MW 10K is a high-molecular-weight fluorescein-terminated fluorescent biodegradable PLGA copolymer designed for long-term biological tracing, stable nanoparticle imaging, and prolonged sustained drug delivery visualization. Equipped with standard FITC fluorescent labeling and fully tunable PLGA lactide ratios, this polymer delivers bright, low-background green fluorescence and enhanced structural stability, perfectly suited for long-cycle in vitro and in vivo biomedical imaging and carrier tracking research.
Basic Specifications
Alternative Name: PLGA-Fluorescein, PLGA-FITC
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Fluorescent Label: Fluorescein (FITC)
Excitation Wavelength: ~495 nm
Emission Wavelength: ~519 nm
Molecular Weight: 10K, Custom
Appearance: Yellow to yellow-green solid
Key Features and Benefits
Stable FITC Fluorescent Labeling: Terminal fluorescein (FITC) functionalization provides consistent bright green fluorescence with standard ~495 nm excitation and ~519 nm emission peaks. It features low biological background interference and high-sensitivity optical signals, supporting label-free real-time visualization and quantitative detection throughout long-term experimental cycles.
Multi-Ratio & Custom Synthesis Support: Includes standard 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio tuning accurately modulates polymer hydrophobicity, degradation kinetics and particle rigidity to adapt to various long-term sustained-release and stable imaging application scenarios.
Enhanced 10K High Molecular Weight Performance: 10K high molecular weight forms dense polymer chain entanglement, delivering superior structural rigidity and morphological stability compared to medium and low-MW PLGA. It features prolonged and uniform degradation behavior, effectively preventing particle deformation and premature drug leakage, making it ideal for long-cycle stable fluorescent formulation preparation.
Superior Biocompatibility & Biodegradability: Possesses excellent physiological compatibility and biosafety, gradually hydrolyzing into non-toxic lactic acid and glycolic acid under physiological conditions. It causes no inflammatory irritation or toxic residue, fully applicable for long-term in vivo tracing and sustained-release biomedical research.
Long-Term Fluorescence Stability: Professional terminal FITC capping technology effectively avoids fluorophore shedding and fluorescence quenching during long-term particle storage, circulation and slow degradation, maintaining stable, repeatable high-sensitivity fluorescent imaging results.
Applications
Long-Term Fluorescent Particle Tracing: Ideal for prolonged real-time tracking and tissue distribution analysis of PLGA nanoparticles and microspheres in cell and animal models, supporting long-cycle biological behavior monitoring.
Prolonged Sustained Drug Delivery Imaging: Enables continuous visual monitoring of long-term carrier degradation, in vivo accumulation, circulation retention and sustained drug release kinetics for long-acting controlled-release formulation development.
Stable Biomedical Fluorescent Labeling: Acts as a high-stability self-fluorescent polymer matrix for long-term degradable biomaterial labeling, biological distribution evaluation and persistent optical detection experiments.
Long-Cycle Formulation Stability Research: Facilitates intuitive assessment of long-term nanoparticle stability, cellular uptake persistence and sustained delivery efficiency for advanced long-acting drug delivery system research.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container to preserve long-term FITC fluorescence activity and polymer structural integrity.
Handling: Avoid strong light irradiation, repeated freeze-thaw cycles and high-temperature environments to prevent fluorescence quenching and premature polymer hydrolysis.
PLGA-Fluorescein (PLGA-FITC), MW 10K integrates high-stability polymer structure, long-cycle tunable degradability and reliable FITC green fluorescence, serving as a high-performance fluorescent tracing polymer for prolonged drug delivery imaging, long-term nanoparticle tracking and advanced biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.