OPSS-Poly(L-Arginine) (OPSS-PArg) is an OPSS-functionalized cationic poly(amino acid) based on poly(L-arginine) that specifically combines guanidinium-rich PArg with a thiol-reactive OPSS group for conjugation and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-arginine) provides multiple positively charged guanidinium groups for electrostatic interactions with anionic molecules and materials.
- Terminal OPSS Group: Provides an orthopyridyl disulfide functionality specifically for selective reaction with compatible thiol-containing compounds.
- Thiol-Reactive Chemistry: OPSS reacts with sulfhydryl groups through disulfide exchange, forming a new disulfide linkage.
- Disulfide Conjugation: The resulting disulfide bond provides a cleavable linkage under suitable reducing conditions.
- Guanidinium-Rich Structure: Arginine side chains specifically provide strong cationic character and support interactions with negatively charged biomolecules.
- Bioconjugation Platform: Supports attachment of thiol-containing peptides, proteins, ligands, and other functional molecules.
- Functional Poly(amino acid): Combines cationic poly(L-arginine) properties with terminal thiol-reactive functionality.
Applications
- Thiol Conjugation: Supports selective coupling with compatible sulfhydryl-containing molecules through disulfide exchange.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, ligands, and other biomolecules.
- Reversible Conjugation: Supports research requiring disulfide linkages that can cleave under suitable reducing conditions.
- Nucleic Acid Complexation: The cationic PArg segment supports electrostatic interactions with negatively charged nucleic acids.
- Nanoparticle Functionalization: Provides a thiol-reactive handle for functionalizing compatible nanoparticles and polymer systems.
- Drug Delivery: Supports development of functional cationic polymers specifically for drug-delivery and formulation research.
- Surface Modification: Enables thiol-mediated attachment to compatible functional surfaces and materials.
- Biomaterial Research: Supports development of functional polymer conjugates, complexes, coatings, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
OPSS-Poly(L-Arginine) (OPSS-PArg) combines cationic poly(L-arginine) with thiol-reactive OPSS functionality and specifically supports disulfide conjugation, biomolecular complexation, surface functionalization, and drug-delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.