Thiol-Poly(L-lysine)-Thiol, MW 16K is a thiol-functionalized cationic poly(amino acid) with terminal thiol groups. It combines an amine-rich poly(L-lysine) chain with reactive thiols specifically for conjugation, crosslinking, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides multiple cationic side-chain amino groups for electrostatic interactions with anionic molecules and materials.
- MW 16K: Provides an intermediate molecular weight polymer specifically for conjugation, crosslinking, and functional material development.
- Terminal Thiol Groups: Thiol functionality at both polymer termini provides reactive sites for thiol-selective chemistry.
- Dual-End Functionalization: Two terminal thiol groups specifically support polymer linking, network formation, and multicomponent material design.
- Thiol-Reactive Chemistry: Supports coupling with compatible maleimide, OPSS, and other thiol-reactive functional groups.
- Disulfide Formation: Thiol groups can form disulfide linkages under suitable oxidative conditions.
- Primary Amine-Rich Structure: Lysine side chains specifically provide additional sites for electrostatic interactions and chemical functionalization.
Applications
- Bioconjugation: Terminal thiols support coupling with compatible thiol-reactive peptides, proteins, ligands, and other molecules.
- Polymer Crosslinking: Dual terminal thiols support crosslinking with compatible multifunctional thiol-reactive compounds.
- Hydrogel Research: Supports development of crosslinked polymer networks and hydrogel systems using suitable reaction partners.
- Nanoparticle Functionalization: Thiol groups provide reactive handles for modifying compatible nanoparticles and polymer assemblies.
- Surface Modification: Supports thiol-mediated attachment to compatible functional surfaces and materials.
- Gold Surface Functionalization: Thiol groups can interact strongly with compatible gold surfaces and nanoparticles.
- Drug Delivery: Supports development of functional cationic polymer systems for drug-delivery and formulation research.
- Biomaterial Research: Supports development of polymer conjugates, networks, coatings, and other functional biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged air exposure. Minimize oxidation of thiol groups during handling and storage.
Thiol-Poly(L-lysine)-Thiol, MW 16K combines an amine-rich poly(L-lysine) backbone with reactive terminal thiol groups, while its dual-end functionality supports conjugation, crosslinking, surface modification, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.