Tritylthiol-Terminated Poly(L-Lysine), MW 8.2K is a cationic poly(amino acid) bearing a trityl-protected terminal thiol. It combines amine-rich poly(L-lysine) with protected thiol functionality specifically for controlled deprotection, conjugation, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides multiple cationic side-chain amino groups for electrostatic interactions with anionic molecules and materials.
- MW 8.2K: Provides a moderate molecular weight polymer specifically for conjugation, surface modification, and functional material development.
- Trityl-Protected Thiol: The terminal thiol carries a trityl protecting group that specifically helps prevent premature oxidation and unwanted thiol reactions.
- Protected Reactive Terminus: Trityl protection keeps the terminal thiol masked until deprotection is required.
- Thiol Activation: Removal of the trityl group exposes a free thiol for subsequent thiol-selective conjugation.
- Thiol-Reactive Chemistry: After deprotection, the terminal thiol can react with compatible maleimide, OPSS, and other thiol-reactive groups.
- Primary Amine-Rich Structure: Lysine side chains provide additional sites for electrostatic interactions and chemical functionalization.
Applications
- Controlled Thiol Conjugation: Trityl protection enables thiol functionality to be exposed before conjugation under suitable deprotection conditions.
- Bioconjugation: The deprotected thiol supports coupling with compatible thiol-reactive peptides, proteins, ligands, and other molecules.
- Polymer Functionalization: Provides a protected terminal reactive group for incorporating poly(L-lysine) into functional polymer systems.
- Nanoparticle Functionalization: The exposed thiol provides a reactive handle for modifying compatible nanoparticles and polymer assemblies.
- Surface Modification: Supports thiol-mediated attachment to compatible functional surfaces after deprotection.
- Gold Surface Functionalization: The deprotected thiol can interact strongly with compatible gold surfaces and nanoparticles.
- Drug Delivery: Supports development of functional cationic polymer systems for drug-delivery and formulation research.
- Biomaterial Research: Supports development of functional polymer conjugates, coatings, complexes, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. After deprotection, minimize prolonged air exposure to reduce oxidation of the free thiol.
Tritylthiol-Terminated Poly(L-Lysine), MW 8.2K combines cationic poly(L-lysine) with a protected terminal thiol. Trityl protection specifically supports controlled thiol activation for conjugation, surface modification, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.