N3-Poly(L-Lysine), MW 7.5K is an azide-functionalized cationic poly(amino acid) based on poly(L-lysine). It combines an amine-rich PLL chain with terminal azide functionality specifically for click chemistry, bioconjugation, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides positively charged primary amine groups for electrostatic interactions and functionalization.
- MW 7.5K: Provides a relatively low molecular weight PLL chain with cationic character and terminal reactive functionality.
- Terminal Azide Group: Provides an azide functionality specifically for selective click chemistry with compatible alkyne-containing molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkynes.
- SPAAC Click Chemistry: Supports copper-free coupling with strained cyclooctynes such as DBCO and BCN.
- Primary Amine-Rich Structure: Lysine side chains specifically provide multiple primary amines specifically for electrostatic interactions and additional functionalization.
- Bioconjugation Platform: Enables attachment of compatible peptides, proteins, ligands, dyes, polymers, and other functional molecules.
Applications
- Click Chemistry: Terminal azide supports CuAAC and SPAAC reactions with compatible alkyne-functionalized molecules.
- Bioconjugation: Enables attachment of compatible biomolecules, ligands, dyes, and other functional compounds through click chemistry.
- Polymer Functionalization: Provides an azide handle for introducing additional functionality onto the PLL chain.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible polymeric and nanoparticle systems.
- Surface Modification: Enables development of functional cationic coatings and modified surfaces for research applications.
- Biomolecular Complexation: The cationic PLL backbone supports electrostatic interactions with compatible negatively charged biomolecules and materials.
- Drug Delivery: Supports development of functional cationic polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymer conjugates, modified surfaces, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
N3-Poly(L-Lysine), MW 7.5K combines an amine-rich cationic PLL chain with terminal azide functionality and specifically supports click chemistry, bioconjugation, polymer functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.