Acetal-Poly(L-lysine), MW 32K is an acetal-functionalized cationic poly(amino acid) based on poly(L-lysine). It combines an amine-rich PLL chain with acetal functionality specifically for controlled functionalization, conjugation, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides positively charged primary amine groups for electrostatic interactions and functionalization.
- MW 32K: Provides a higher molecular weight PLL chain with multiple lysine residues and abundant primary amine functionality.
- Acetal Functionality: Provides a protected aldehyde precursor that can specifically generate reactive aldehyde functionality under suitable hydrolysis conditions.
- Controlled Activation: Acetal chemistry allows researchers to expose aldehyde functionality when needed for subsequent conjugation.
- Aldehyde Functionalization: After deprotection, the resulting aldehyde can react with compatible aminooxy or hydrazide-containing molecules.
- Primary Amine-Rich Structure: Lysine side chains specifically provide multiple primary amines for electrostatic interactions and additional functionalization.
- Bioconjugation Platform: Combines cationic PLL properties with an activatable terminal group for controlled conjugation strategies.
Applications
- Controlled Conjugation: Acetal functionality provides a protected reactive group for activation before conjugation.
- Bioconjugation: After acetal deprotection, aldehyde functionality supports coupling with compatible aminooxy and hydrazide-containing molecules.
- Polymer Functionalization: Provides an activatable terminal handle for preparing functional PLL conjugates and hybrid materials.
- Nanoparticle Functionalization: Supports development of functional polymeric and nanoparticle systems using compatible conjugation chemistry.
- Surface Modification: Enables development of functional cationic coatings and modified surfaces for research applications.
- Biomolecular Complexation: The cationic PLL backbone specifically supports electrostatic interactions with compatible negatively charged biomolecules and materials.
- Drug Delivery: Supports development of functional cationic polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymer conjugates, surfaces, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to acidic conditions unless acetal deprotection is intended.
Acetal-Poly(L-lysine), MW 32K combines an amine-rich cationic PLL chain with activatable acetal functionality and specifically supports controlled conjugation, polymer functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.