Poly(L-Glutamic Acid), MW 20K is a biodegradable, carboxyl-rich poly(amino acid) composed of L-glutamic acid residues. Its polyanionic character specifically supports biomolecular interactions, polymer functionalization, conjugation, and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) consists of repeating L-glutamic acid residues and provides a biodegradable polymer framework.
- MW 20K: Provides a higher molecular weight polymer chain with multiple glutamic acid residues and abundant carboxyl functionality.
- Carboxyl-Rich Structure: Pendant carboxyl groups provide multiple sites for chemical modification and conjugation.
- Polyanionic Character: Deprotonated carboxyl groups provide negative charge under suitable pH conditions.
- Electrostatic Interactions: The anionic polymer can interact with compatible cationic molecules, polymers, proteins, and other materials.
- Functionalization Platform: Carboxyl groups specifically support activation and coupling with compatible amine-containing molecules.
- Bioconjugation Potential: Activated carboxyl groups can specifically support conjugation with compatible peptides, proteins, ligands, and other amine-containing compounds.
Applications
- Polymer Functionalization: Pendant carboxyl groups provide multiple sites for introducing additional functionality.
- Bioconjugation: Activated carboxyl groups support coupling with compatible amine-containing biomolecules and ligands.
- EDC/NHS Coupling: Carboxyl groups can undergo carbodiimide-mediated activation for conjugation with compatible primary amines.
- Biomolecular Complexation: The polyanionic backbone supports electrostatic interactions with compatible positively charged biomolecules and materials.
- Nanoparticle Research: Supports development and surface modification of compatible polymeric and nanoparticle systems.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Surface Modification: Carboxyl-rich polymer chains can specifically support development of functional coatings and modified surfaces.
- Biomaterial Research: Supports development of polymer conjugates, functional materials, nanoparticles, and related biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Poly(L-Glutamic Acid), MW 20K provides a biodegradable, carboxyl-rich poly(amino acid) platform with polyanionic properties and specifically supports polymer functionalization, bioconjugation, biomolecular interactions, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.