N3-Poly(L-Glutamic Acid), MW 10K is an azide-functionalized, carboxyl-rich poly(amino acid) based on poly(L-glutamic acid). It combines terminal azide functionality with a polyanionic polymer chain specifically for click chemistry, bioconjugation, and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) specifically provides a biodegradable polymer framework with abundant pendant carboxyl groups.
- MW 10K: Provides an intermediate molecular weight poly(L-glutamic acid) chain with multiple glutamic acid residues and abundant carboxyl functionality.
- Terminal Azide Group: Provides a reactive azide handle specifically for selective click chemistry with compatible alkyne-containing molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with compatible terminal alkyne-functionalized molecules.
- SPAAC Click Chemistry: The azide supports copper-free coupling with strained cyclooctynes such as DBCO and BCN.
- Carboxyl-Rich Structure: Pendant carboxyl groups provide additional sites for chemical modification and conjugation.
- Polyanionic Character: Deprotonated carboxyl groups specifically provide negative charge under suitable pH conditions.
- Multifunctional Platform: Combines terminal azide reactivity with the carboxyl-rich properties of poly(L-glutamic acid).
Applications
- Click Chemistry: Terminal azide supports CuAAC and SPAAC reactions with compatible alkyne-functionalized molecules.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, dyes, polymers, and other functional molecules.
- Polymer Functionalization: Provides an azide handle and pendant carboxyl groups for preparing multifunctional polymer conjugates.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible polymeric and nanoparticle systems.
- Surface Modification: Enables development of functional polymer coatings and modified surfaces through compatible click chemistry.
- Ligand Conjugation: Supports attachment of compatible alkyne- or cyclooctyne-functionalized ligands for research applications.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
N3-Poly(L-Glutamic Acid), MW 10K combines a carboxyl-rich poly(amino acid) chain with terminal azide functionality and specifically supports CuAAC and SPAAC click chemistry, bioconjugation, polymer functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.