Mal-PEG2-hydrazide
Mal-PEG2-hydrazide is a bi-functional PEG linker featuring a maleimide group for thiol-specific conjugation and a hydrazide group for efficient reaction with aldehydes and ketones to form stable hydrazone bonds. Its PEG2 spacer enhances solubility and reduces steric hindrance, making it suitable for various bioconjugation and chemical biology applications.
Key Features
- Dual Functional Groups:
- Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
- Hydrazide: Reacts with aldehydes and ketones for stable hydrazone formation.
- PEG Spacer:
- PEG2 enhances solubility and flexibility.
- Reduces steric hindrance in conjugation reactions.
- Biocompatibility:
- Non-toxic and suitable for use in biological environments.
Applications
- Bioconjugation: Attaches proteins, peptides, or other biomolecules via thiol and carbonyl chemistry.
- Drug Delivery: Acts as a linker for creating conjugates with improved solubility and stability.
- Nanotechnology: Functionalizes nanoparticles and biosensors for specific targeting and labeling.
- Chemical Biology: Enables site-specific labeling and crosslinking in complex systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
