Azido-PEG16-NHS ester CAS:1108750-59-9 contains an azide functional group (-N3) attached to the end of a PEG chain through an NHS ester linker. The azide group is known for its ability to react with other molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC), a powerful bioorthogonal reaction.
Azido-PEG16-NHS ester has been extensively utilized in the development of novel drug conjugates and imaging agents. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via CuAAC reaction. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
