Azido-PEG12-NHS ester
This product is a heterobifunctional PEG linker containing a terminal azide, a PEG12 spacer, and an NHS ester. It specifically enables click chemistry and amine conjugation, offering solubility, long-chain flexibility, and dual reactivity.
Key Features and Benefits
-
Azide Group: Reacts with alkynes via CuAAC or SPAAC click chemistry.
-
NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
-
PEG12 Spacer: Provides hydrophilicity, solubility, and extended length.
-
Dual Reactivity: Combines click chemistry with amine conjugation.
-
High Purity: Ensures reproducibility in bioconjugation and synthesis workflows.
Applications
-
Bioconjugation: Links azide-modified and amine-containing biomolecules.
-
Probe Development: Builds multifunctional probes for diagnostics and imaging.
-
Drug Delivery: Provides PEG scaffolds with orthogonal reactive groups.
-
Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual chemistry.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure.
This product integrates azide click chemistry with amine coupling in a PEG12 scaffold, specifically offering solubility, flexibility, and multifunctionality.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
