PTAD-Azide: Overview and Applications
Product Summary
PTAD-Azide (CAS: 1313211-52-7) is a linker with a PTAD group that targets tyrosine and an azide for click chemistry. It labels the tyrosine side chain in proteins, peptides, and small molecules, working well in aqueous buffers without metal catalysts. The linkage is stable, enduring temperature, pH changes, and blood plasma conditions.
Key Benefits
- Tyrosine Selectivity: Targets only tyrosine, avoiding cysteine and lysine.
- Specific Labeling: Modifies only tyrosine’s phenolic side chain.
- Buffer Compatibility: Works across various pH levels in water-based buffers without metal catalysts.
- High Stability: More stable than maleimide under heat, pH extremes, and in plasma.
Applications
- Bioconjugation and Labeling
- Enables specific tyrosine labeling for accurate detection.
- Click Chemistry
- The azide group allows CuAAC click chemistry with alkynes for flexible bioconjugation.
- Drug Delivery
- Provides stable and targeted attachment in drug delivery systems.
- Surface Functionalization
- Ideal for adding bioactive molecules to surfaces, useful in biosensors and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
