PP2, AGL 1879, (CAS: 172889-27-9) is a reversible, ATP-competitive inhibitor of Src-family kinases, with IC50 values of 4 nM for Lck and 5 nM for Fyn. It is widely used in research to block key kinases like Src, Lck, and Fyn, especially in cancer and immune studies.
Applications:
- Cancer Research:
Src-family kinases drive cancer cell growth. Researchers use PP2 to block Src activity, helping them explore cancer pathways and find new therapeutic targets. - Immune System Studies:
PP2 effectively inhibits Lck and Fyn, making it useful for studying T-cell activation and immune responses. This research helps in understanding autoimmune diseases and advancing immunotherapies. - Neurobiology:
In the brain, Src-family kinases regulate neuron activity. PP2 allows scientists to study how blocking these kinases affects brain function and diseases like Alzheimer’s.
Conclusion:
PP2 is a powerful tool for investigating cell signaling in cancer, the immune system, and neurobiology. Its selective inhibition of Src-family kinases opens new doors for therapeutic discoveries.
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