DMT-dA(bz) Phosphoramidite
This product is a DNA synthesis reagent for incorporating deoxyadenosine into oligonucleotides. It features a DMT-protected 5′-hydroxyl, a benzoyl-protected exocyclic amine, and a CE phosphoramidite for automated coupling. The DMT group supports efficient stepwise elongation, while the benzoyl group protects the base during synthesis. This reagent is especially used in custom oligonucleotide synthesis, structural biology, and nucleic acid research.
Key Features and Benefits
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DMT Protection: Ensures controlled 5′-hydroxyl deprotection during synthesis cycles.
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Bz-Protected Amine: Provides stability for the adenine base throughout synthesis.
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CE Phosphoramidite: Compatible with automated solid-phase DNA synthesis.
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High Purity: Manufactured to ≥98% purity for reliable coupling.
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Standardized Design: Used broadly in custom oligonucleotide production.
Applications
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DNA Synthesis: Incorporates adenine into custom oligonucleotides.
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Structural Biology: Supports studies of DNA duplex stability and interactions.
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Diagnostics: Builds DNA probes for hybridization assays.
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Research Tools: Supplies high-quality blocks for custom gene synthesis.
Storage and Handling
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Storage: Store dry at –20 °C under inert atmosphere.
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Handling: Use under anhydrous conditions; phosphoramidites are moisture-sensitive.
This product offers reliable incorporation of adenine bases into oligonucleotides, specifically supporting DNA synthesis, diagnostics, and nucleic acid research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
