Bis-sulfone-PEG24-m
Bis-sulfone-PEG24-m is a bioconjugation reagent combining a reactive bis-sulfone group and a PEG24 chain. The bis-sulfone group is a powerful bidentate alkylation reagent that reacts with cysteine thiols from reduced disulfide bridges in proteins, allowing precise site-specific conjugation. The PEG24 moiety enhances solubility and stability, facilitating easy conjugation with biologics.
Key Features and Applications:
- Bis-sulfone Group: Reacts with cysteine thiols to form a stable three-carbon bridge, preserving protein structure and function.
- Two-Step Conjugation:
- Disulfide reduction releases cysteine thiols.
- Bis-alkylation re-forms a bridge, attaching functional groups while maintaining protein integrity.
- PEG24 Chain: Improves solubility and stability, aiding bioconjugation without compromising biological activity.
- Histidine Conjugation: Targets histidines in His-tags without metal chelation, retaining protein function.
Bis-sulfone-PEG24-m provides a versatile approach to bioconjugation, enhancing drug delivery and targeted protein modifications with minimal impact on function.* (see Selected References section).
*https://pubs.rsc.org/en/content/articlehtml/2019/sc/c8sc03355b
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
