Alkyne-PEG4-SS-amine is a bifunctional linker featuring an alkyne moiety, a polyethylene glycol (PEG) spacer, and a disulfide bond (SS) conjugated to an amine group. The alkyne group enables click chemistry reactions, while the PEG4 spacer enhances solubility and biocompatibility. The disulfide bond allows for cleavable linkages, and the amine group provides a site for bioconjugation.
In pharmaceutical research and development, Alkyne-PEG4-SS-amine is extensively utilized as a versatile linker in the synthesis of bioconjugates, such as antibody-drug conjugates (ADCs) and targeted drug delivery systems. Its unique combination of functional groups offers site-specific conjugation, tunable drug release, and improved pharmacokinetic properties, contributing to the development of more effective and safer therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
