DBCO-PEG-SC, MW 2K(DBCO-PEG-NHS) is a bioconjugation reagent widely used in pharmaceutical research and development for the functionalization of molecules such as peptides, proteins, and antibodies. It consists of a DBCO (dibenzylcyclooctyne) group, a PEG (polyethylene glycol) chain, and an NHS (N-hydroxysuccinimide) ester group. The DBCO group is an alkene with high reactivity towards tetrazines and azides, enabling specific and rapid covalent conjugation with the target molecule. The PEG chain improves solubility, stability, and biocompatibility of the conjugate, while the NHS ester group provides an active site for conjugation through amine groups present on the target molecule.
DBCO-PEG-SC, MW 2K has been used in various pharmaceutical applications, including drug delivery, imaging, and diagnostics. It is particularly useful in the development of antibody-drug conjugates (ADCs), where it is used to conjugate cytotoxic drugs to antibodies for targeted cancer therapy.DBCO-PEG-SC, MW 2K has also been used for the functionalization of nanoparticles, enabling targeted drug delivery to specific cells or tissues.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.